Aplasia Cutis Congenita in Twins and Low-Molecular-Weight Heparin: A Case Report and Literature Review

Rim Ben  Aziza; Hajer  Chourou; Amina  Aounallah; Samia  Kacem; Radhouane  Achour; Myriam  Cheour

Rim Ben Aziza Neonatal Medicine and Intensive care Unit; Maternity and Neonatology Center of Tunis, Faculty of Medicine of Tunis, El Manar University of Tunis, Tunis,
Hajer Chourou Neonatal Medicine and Intensive care Unit; Maternity and Neonatology Center of Tunis, Faculty of Medicine of Tunis, El Manar University of Tunis, Tunis, Tunisia
Amina Aounallah Department of Dermatology, Farhat Hached Hospital, Sousse, Tunisia
Samia Kacem Neonatal Medicine and Intensive care Unit; Maternity and Neonatology Center of Tunis, Faculty of Medicine of Tunis, El Manar University of Tunis, Tunis, Tunisia
Radhouane Achour Emergency Department of Gynecology and Obstetrics, Maternity and Neonatology Center of Tunis, Faculty of Medicine of Tunis, El Manar University of Tunis, Tunis, Tunisia
Myriam Cheour Neonatal Medicine and Intensive care Unit; Maternity and Neonatology Center of Tunis, Faculty of Medicine of Tunis, El Manar University of Tunis, Tunis, Tunisia

Abstract

Aplasia Cutis Congenita (ACC) is an uncommon disorder characterized by a skin defect in localized or widespread area at birth. It can be isolated or be a part of a heterogeneous group of chromosomal or malformative syndromes. The underlying etiology of ACC remains poorly understood. Many factors have been considered as possible causes. Two isolated cases of scalp ACC have been reported with a possible association with low-molecular-weight heparin. Single offspring with ACC have been described in literature, but cases in twins are rarely reported. We report a case of a dizygotic twin pregnancy, with in-utero exposure to low-molecular-weight heparin, in which both the male and female twins had matching areas of aplasia cutis on their scalps.