Serum Interleukin and complement, levels in women with Ovarian Cancer

Abstract

Background: Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is considered as a risk for ovarian carcinoma, and it contributes in all grades of tumor progression. Inflammation involved in the development of cancer cell and can be caused by an increase in the formation of pro-inflammatory cytokines. Objective: This research was conducted to assess serum Interleukin, complement levels C3 and C4 levels in ovarian cancer patients and to assess their impact in disease action. Patients and methods. The present study is composed of 85 women (mean age = 62.03±12.4 yrs) with clinically and pathologically confirmed ovarian cancer and 65 healthy women as a control group (mean age = 61±12.1 yrs). The measured biochemical parameters included: the level of serum Interleukins (IL-4, IL-6, IL-8) and complement levels  C3 and C4. Results: The results demonstrated significantly high values of serum Interleukin levels  (IL-4, IL-6, and IL-8) (p<0.001, p<0.002, p<0.01) respectively and significantly high  values  (p < 0.01, p < 0.012) respectively in serum  complement levels  C3 and C4 in ovarian cancer in comparison with control group. Conclusion: An elevation of serum Interleukins levels, and complement levels C3 and C4 in cases of Ovarian carcinoma in our study is importance as a marker of the disease.